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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4388e2dd1e14b916991d66668486f74ffb747b2bfb1f6b738ee9ee75163580b4' 
  AND token = 'VGIDq40LxB1dywsJ4SMMyFUBtxU3u+FD6eFwWjU9s3E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}