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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49dd2c8d0efb3b18d24bd8fd0a92cf26f3fa427b740425d05e5970d90fde26ed' 
  AND token = '1EO2ryPCr+pfCleYYBTj/OM1G+LzttIZ+JzcZnYlPz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}