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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9453635d69b917189e57a919d336536346fbd4017d5cdee600dbd31d87b6e3e4' 
  AND token = '9czF/Q5b/rbJ2mG2iBjQYG5k9iYh0NVOfH7PfTvkgl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}