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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c649a560a55dd79c90d551bdadc80ab9b4998ab3d641b36532c12230994722ff' 
  AND token = 'weTMoGoHwoNyZGxp3lsf3UfRvPaSrkzKi6ZSg1g+VU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}