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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b8822ca3268e9aa803f80aec8a3d1d9f137c905caf948969375df3a7c0b2b00' 
  AND token = 'g2yuYH0qCNzWhMSjYAO8XZY1EbseUxtPnX/Z3GjpAXg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}