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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '175308afc09cb4c0d457461158d52c0155df71e27e855cef30722386ff8a38a8' 
  AND token = 'n7ip0tZt8P4gM4mc4OK8oLrBB+ZaFzMV6hY2sK8KKm4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}