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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21cd556df618b2158df763d3f603f553b1b394067f51c11e0ac30517bfaf2445' 
  AND token = 'LnaliIT01jcBDytpfdm1WmqnikxjIJDrsijaeNfwfV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}