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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c59eb1c24eded126fb6ec31493a24cd56bfacd48d7a53f8a38b7e256a373e661' 
  AND token = 'pAdLWxmJIovinmDm0LyAFHDA6BCQghZw5d+2OmdePqA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}