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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af716ec42ac3be6b94869ff8453011c2fced668f291f60f1c8f975381c82351c' 
  AND token = 'qRL1P3G+GRMnM7GL1/GjNBEKr80oIudr7KFD6Psyejg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}