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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21851aeec03cb0ee60ed2fdd41eebde0d91371f5d2da6247a2676cb8d26f27c9' 
  AND token = 'QpjdzLeDy+VB7ZD1YMHXTzISglw6lDMbeLSeGsUw8hg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}