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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f6b2ec5aefcc70010a7b6f0c47aafa772f28c1307070b2ce0b88761b25478200' 
  AND token = '1DhqlF4JuW0NHiDTksfEqRNtqWzKToF9dQMze30Id5M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}