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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d4123f27785446b523c4b82962ad17255e97e4a371a6c2eb07ef673cbb8be10' 
  AND token = 'WE/a4edgl7lPPpvyYGllSpj3V8NeQ3y2gQxQ2OSAotI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}