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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b65b0370e2e707a25a461934bfdee3b6fb3d5201f0f172ff0881e786f47cf6ad' 
  AND token = 'I/ZC+PVbFMK0AjFh7xfz/cmLSHaQAlht/Zxf1MF56pk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}