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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '333d01e4e73027d46d63abc7a1f7c9777eed77486ac31f617fc6040b211f9587' 
  AND token = '+7D/6MPisD0HXMp8ILFbVKm6zxCiYu2dQ/vjKLKorD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}