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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d45e331e19d38e9e8829e36dc527e2bf0f3ac1c220995d7782b414e49b9eb2c' 
  AND token = 'MlrAQGrTHQqEJ5e4XT01Ohwa9mkINyuGDDREN9eVS1E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}