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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b1fcf22d96f781fe9790101f32ea849b4f602c7f16d0c75878cfcebc80b5750' 
  AND token = 'sDUQmYlyQnUadRQ2vvp2Bo7XKhJyzq9dJ4gpgAIT3N8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}