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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4a7790ac53e7e3418f88957ba2d2a3c7e2f734a8b4d0644724d201b49535f2c' 
  AND token = 'pLrtdYMkTnFphFrB3bSqnmRX0PBbsc8dgDZsGuhpCr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}