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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44362bbf4d0e02836c89b34efd74e6cf683833832c9308be7f9ff271484f412c' 
  AND token = 'ICPYYjS1n+XEVXsoEZUTTkZZoRRlcvFPKnvKvWwe/Co=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}