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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e21dcbe6f60b259d7006ae9611bbdbf175620ee49fba9d455f7c49656a3b6749' 
  AND token = 'E/+rZs92AIMoFRMOG3nuEGxuOURHw3wbEg3ojsoHBuA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}