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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75de4249ef9099b3b210e23a6aed000fe157a87d3f980e8e142af0fc6cb3c193' 
  AND token = '2cJskkF+DzZeAnKza2+knWiQQhx4w4UM0Pc5jruXs1E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}