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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f049b1f894c08b69e3e4b8b50b55a4c56032b3f6e603559d37c84940020b3554' 
  AND token = 'uSQcbZzp2F9m0PKNpjTQh9H3VJc1tj4eKkx7+JTUsVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}