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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '228e9f20651ea0bb4f743f8793c1711b8f26d8f75c981748a3680391082f6440' 
  AND token = 'qmn0nz9Hj8m/MQoGbiyF18xD0zcC78ZkwBua19qzKQs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}