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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '277f5299dfd887414ec2601f8ca2f067a9385e580c8453c3557f41c6dccc3646' 
  AND token = 'zMgyD93W0UvwEe+bPF6+4wO+zkl9FJyFoOFxp9udFpw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}