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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b555378224b152c62896f925305f40b3a7f2c5d66229c2537da59d178c4c8aa' 
  AND token = 'FA2t+h7DEcD8KNYaCR2AKFk//yfd1tbSUziq9kmk7lY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}