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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b800785b2f7128dddbe3dacad9191d380e5d5c658a10bedc859caa14152437d0' 
  AND token = '+vO61jfXxjxsS0+4WPVcq9n22/6n9sjxw1QuNFMFiS8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}