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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45a2d0b06057b9651670e2892043b67711c526cd2762286bc9301f161e2725af' 
  AND token = 'deV68MSC3XX7SKWo5sL+3rPRCa5DfOiA2VUyjcHmepY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}