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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4f3f6ac484cb238a5f11433bb2304a8765e71be90f538a1804f68e1f77e6a50' 
  AND token = 'hrsoEN4jaAWk3RdUWxlLG4WwEDtjiXNk1oy0NnPXoY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}