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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49066b82f772047d7f0002074ae66c29011b3557598e506f7b2f8feddb44163b' 
  AND token = '4gWOCl5pswAPb8Up5R7mMB1Luyipa4qROeqsuEPLKP0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}