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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '344d95253ca00b3d9c9c900828cf59799aedf90a0865596db5e9af68b859f5fd' 
  AND token = '64S6dyowGpyQvpF769Lz/kwNgELLTNYPBAIwE7+N0BI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}