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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81f55afc37e70b111add768fdb322815fad6c08addb84bc8e1cf529292f72009' 
  AND token = 'oRk1YKTGGS+Nu397/4Cl1yqTchZXOA5/HIpxHdPO3uo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}