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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4281f9482f6a51f5c7a3b785d1e597627f6a0fed3878e65b849037ab9c30d8d' 
  AND token = 'WBe/WnZoScns0hrY3XsMi5iDqbKYOeDrjZJ6iccFk5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}