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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45880ce684b7d33ea3328e0a82c67afa211d6317ff06ac5266ff30b2151130c9' 
  AND token = 'pyq94es4JQUU6hfo+UJa3YPV1FANt01JqFTsuwoPzoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}