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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '541180c7f1b8d154510bdb9b505ad8acc4aa549da60ed15f3d26af06e1f0038a' 
  AND token = 'QUf9JCO/IgVSXXQDNPUkCCPX10ZO36VDRBAsuy8ZcAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}