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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '263ba89384b52bbf4d2c566ca3dcdb32f42b6a05204528611319ad614c038867' 
  AND token = 'ydb4bgFz+s/iPtJSob2qgs5LzSI0sDZ5zl8MQL39WD8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}