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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '99424664bfc5c37b41508e0f75362f621612e06101ea1266d3bf387c03f53c42' 
  AND token = 'A72I2/pD8ClTA2AnSJGZNT70JBFyf9n8JPKdU5mwxGs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}