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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d0b6846b20a8f693edc9a7925e6b114b2a4b417421c568e48026b8f46c32e69' 
  AND token = 'EfqlQ+YjqUP6iWyiJh2nTu8oE+BILpzkRQopq+o9MP8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}