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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ab5460fbf57e4734186681d4af4d2e4f1aa662eeed8696b15ebab6190d0429a0' 
  AND token = 'BEcUDZd//mTIz8IZwc4FLyyS9eHmQF6+6PGNSOkvkCA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}