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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b46d399c4606fbc98b20325099bbb5c35e1339e9b18c43d40174e957d5f88563' 
  AND token = 'u1+tAz41sXvtz/TFJBG+Y/e+yim6RpDL4oGxyu58r/A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}