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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '68e054e3ec1a409fa8f12630350e4e17560b1064bc91ddee681dde08ac8f5980' 
  AND token = 'W1WP4+KM7gKH9B3qrdwzaz5BmSVyMWTaJh1TcLwmm/w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}