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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3341926a44cfa0c1f67bfdc0f283e45192dc30cd52745ef923022d4e2837e0af' 
  AND token = 'D2ZEIHk9XL2i3ohuO53F/iZPsK43Y6VgjjOO94vMrCE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}