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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '424005cb1cbb54ed9a7b77a9bcccbabdfa382ccd058068e9d2ec1b2c0946e144' 
  AND token = 'hCQ5btXpC0+GRg+B0z0XdMNOB/l3te80qS5ErN6XzV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}