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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22451f48a2c31365cff53cdaba6c30495d9603e18ea9218f20777f13887b7f51' 
  AND token = 'GDeP4U9SAjnksfFL0Sn7i5Olvn+2PnS81hGad6h/w7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}