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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d45a2dfc5010b31dd87b34091a88bc0e65f0dc183f2e5748740bdf930de3425' 
  AND token = 'N0CN1mbLFhW+sd0KeRD5NgxTRMxI6fY0Qh+GlzGa0Pw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}