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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f6e6de30edd8b0394181c46a8bee4e2f32a08b75a4760e77a8906b86b9d9cf2b' 
  AND token = 'umpKO+eLMMfRrz4KPnaYXzC4uOPUjmuBtYgMWcVxzfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}