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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e78b7c73e5389321fce58f2f641c3f323c0f8614f76fae0d48ffd2115b725b74' 
  AND token = 'OlTx0F7+yJERUVRdnFD4D3kcN1WgIGjpQvjxUEcoDhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}