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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '404dfe5575328b0ba76c51d076d07017aceea4642e266350477c78fd3e9a3f46' 
  AND token = 'juchmzgytVTk+8BYs52hhRMDWak5sLt0hi+lmGBL1nE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}