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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd46acc420b2adf3aa90f2f7bd2709035a3157049788c479144ef31f52374861a' 
  AND token = 'ktVeXIuvAg2inTbIGZUMMO4J1y8FuRvGBEFPy9LmNkc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}