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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14972703487e218ce8965cc609e2f6dc04ff6e25d5e04e02994197306454883a' 
  AND token = 'o/Bfq2QUWCJkFlDMi/iHthRvrq2kUByw9e1OXluCA/E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}