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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e3877f8bac86cff3e1a099d9fc9650ff52b54721e6c9894d92728417479c271' 
  AND token = 'qjIXpV10CTko0hpfTfm9TuRPJiM/6nhOORe9tTJkJ2k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}