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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e365c8d0d0a2ae8af54425989c171a565327bc5f00c8994df01fe34dfa0e3234' 
  AND token = 'iy3kQ2+SNDFjEiITC3rMu9w2R8pjfUtNRBEoPMRsFDA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}